2/24/2023 0 Comments Red devil obd![]() ![]() The compounds worked as well as the original drug, if not better, at killing cultured cancer cells and were nearly as effective at slowing tumor growth in mice. In the new work, the Leiden team tested two anthracycline variants that remove histones without breaking DNA: an approved cancer drug called aclarubicin, and a tweaked version of doxorubicin they call diMe-Doxo. This chromatin damage apparently interferes with the transcription of genes into proteins and other cell processes, Neefjes says. But the researchers found doxorubicin also kills cancer cells by dislodging histones, the spherical proteins that DNA coils around like a spool to form a structure known as chromatin. The textbook explanation is that the drugs kill rapidly dividing cells, such as those in a tumor, by blocking an enzyme they need to untangle and repair DNA as they replicate. But chemist Jacques Neefjes and his team at Leiden University and collaborators tried a different approach based on a surprising finding about how the drugs fight cancer, which they and a separate U.S. Researchers have tried to reduce the heart risks by, for example, packaging the drugs in fat so they will home in on tumors, with limited success. Many childhood cancers are treated with high doses of the drugs, but cardiac problems sometimes haunt survivors later in life, along with a risk of new tumors, which doctors have attributed to DNA damage from the drugs. They have antibiotic properties but also proved to be some of the most potent chemotherapies ever found anthracyclines are used to treat 1 million cancer patients each year, particularly those with leukemia and breast cancer.īut because anthracyclines can cause heart damage, physicians often avoid giving them to elderly patients. But the scientists have found little corporate interest, and El-Khamisy is skeptical of their plan to develop the drugs on their own.ĭoxorubucin belongs to a class of compounds known as anthracyclines, which were originally extracted from Streptomyces bacteria. The team now plans to test two potentially safer versions of doxorubicin's drug class in people. ![]() "This idea was floating around in the literature for many years, but it has not been proven experimentally," says Sherif El-Khamisy, who studies DNA repair at the University of Sheffield. The work, from an academic team in the Netherlands, upends conventional thinking about doxorubicin and related drugs, suggesting they do not need to directly damage DNA to kill cancer cells. ![]() But a new study reports the drug can be tweaked to reduce its most punishing side effect, cardiac damage, without blunting its ability to curb tumors. Can the red devil be defanged? Doxorubicin, an old chemotherapy drug that carries this unusual moniker because of its distinctive hue and fearsome toxicity, remains a key treatment for many cancer patients. ![]()
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